Nailing upset picks is one of the fastest ways to set your 2021 NCAA bracket apart from the competition in your March Madness pools. However, if you get too carried away, you’ll have too much red running through your 2021 March Madness bracket to be a factor in the standings. It’s all about finding balance. Now that the 2021 NCAA Tournament bracket is set, it’s time to analyze all of the March Madness 2021 matchups.

Oklahoma State was hoping to get a No. 2 or 3 seed after winning the Big 12 Tournament, but wound up as a four. The Cyclones are now staring down a potential matchup with Tennessee in the second round and a potential Ayo Dosunmu vs. Cade Cunningham matchup in the Sweet 16. How deep should you have the Cowboys advancing in your 2021 March Madness brackets, and which double-digit seeds should you back in The Big Dance? Before making any 2021 March Madness predictions, be sure to check out the 2021 NCAA Tournament bracket picks from the advanced computer model at SportsLine.

Last tournament, SportsLine’s computer simulation nailed massive upsets, including huge wins by No. 13 seed UC-Irvine over No. 4 seed Kansas State, No. 10 seed Florida over No. 7 seed Nevada, and No. 12 seed Oregon over No. 5 seed Wisconsin.

This model, which simulates every game 10,000 times, has nailed 15 of the 26 first-round upsets by double-digit seeds the past four tournaments and nailed 14 teams in the Sweet 16 last time.

There’s simply no reason to rely on luck when there’s proven technology to help you dominate your 2021 March Madness pools. Now, the model has simulated every possible matchup in the 2021 NCAA Tournament and revealed its bracket. You can only see it over at SportsLine.

Top 2021 March Madness bracket upset picks

One team set to pull off a shocking upset in 2021 March Madness brackets: No. 9-seed St. Bonaventure knocks off No. 8 LSU in a first-round matchup in the East. LSU is coming off a disheartening 80-79 loss to Alabama in the SEC Tournament title game in which just about everybody but Trendon Watford struggled to shoot the ball.

Watford went 13-for-23 with 30 points in the loss, while the rest of the roster went 17-for-51. Now, they’ll take on a St. Bonaventure defense that has stifled the majority of its opponents on the way to a 16-4 season in which it won the A-10 regular season and tournament titles. The Bonnies held the opposition to 38.9 percent shooting (eighth nationally) and allowed just 60.4 points per game during the season. That’s a big reason why the model says St. Bonaventure is positioned well to pull off the upset in the first round.

Another huge curveball in the East Region: No. 12 seed Georgetown pulls off the upset against No. 5 seed Colorado. The Buffaloes are led by McKinley Wright IV, who leads Colorado in a number of categories, including points (15.5), assists (5.6) and steals (1.1). The senior guard has scored at least 18 points in four of his last five games.

However, Colorado faces a Georgetown team that will enter this matchup full of confidence. The Hoyas lost eight of their first 11 games this season, but Patrick Ewing’s squad has found its form in recent weeks. The Hoyas took down the Big East Tournament after winning four straight games as underdogs, which included a dominant 73-48 victory over Creighton in the title game. Georgetown was able to secure those positive results thanks to its suffocating defense, which has held its opponents to 58 points or fewer in three of its last four games.

How to make 2021 NCAA Tournament bracket predictions

SportsLine’s model also has one region where you need to pick the No. 2 seed, while the Nos. 10, 11 and 13 seeds all deliver huge first-round upsets. Nailing those picks could literally make or break your bracket.

So what’s the optimal NCAA Tournament 2021 bracket? And which underdogs shock college basketball? Visit SportsLine now to see which No. 2 seed you need to target, and see which region you need to pick the 10, 11, and 13 seeds, all from the model that’s called 15 of the 26 first-round upsets by double-digit seeds in the last four tournaments.